Runtime Flow v1.1.1 adds integration with Visual Studio 2010. Toolbar, Flow and Summary windows, go to source – everything works in VS 2010 IDE now:
Runtime Flow integrated with Visual Studio 2010
Monitoring of .NET 4.0 applications is also now supported:
Monitoring summary of a .NET 4.0 WPF application
CLR v4 adds ability to run several CLR instances side by side in a single process. It rarely occurs in practice (see Common in-proc SxS scenarios) so currently Runtime Flow monitors only the first runtime loaded and ignores the rest.
Runtime Flow blog (Understanding a control flow in a running .NET application) 